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Loxo@Lilly Senior Scientist/Principal Scientist, PBPK Modeling (Multiple Locations) in Des Moines, Iowa

Loxo@Lilly conducts discovery research, clinical development and regulatory affairs for oncology, with the goal of creating a pipeline of therapies that have the potential to make a meaningful difference for patients. Loxo@Lilly was created in December 2019, combining the Lilly Research Laboratories oncology organization and Loxo Oncology, which was acquired by Lilly in early 2019. The unit has team members in Louisville, CO, Indianapolis, IN, New York City, NY, South San Francisco, CA, San Diego, CA, Stamford, CT, and Madrid, Spain.

Loxo@Lilly is seeking a highly motivated PBPK modeler join our DMPK team. The ideal candidate will have strong background and expertise in pharmacokinetics (PK) and ADME concepts as well as hands-on experience with PBPK modeling. This position will contribute to the conduct of mechanistic PBPK modeling, human PK predictions, PBBM, and DDI projections to support Discovery and Development projects, enabling compound progression from discovery to early stages of clinical development.

Roles and Responsibilities for the Position:

  • Work closely with Discovery Project teams to influence programs at TPP design, lead optimization, candidate seeking and nomination.

  • Utilize PBPK and translational modeling tools to enable human PK projections throughout the life of a program

  • Evaluate and guide novel in vitro tools and methodology to improve prediction of human PK

  • Proactively lead cutting edge effort to build and refine PBPK models for novel drug modalities (covalent inhibitors, PROTACs, PPI’s etc.)

  • Liaise with DMPK, discovery biology/pharmacology and clinical scientists to generate data and knowledge supporting the build-up of translational, mechanistic models

  • Ensure communication is effective and clear for internally and externally on topics related to PBPK, translational modeling and simulation, human PK and DDI prediction

  • Keep abreast of emerging literature and science in modeling and in vitro approaches

Required Qualifications and Preferred Background:

  • Bachelors, Masters, or PhD with 0-4 (PhD), 8-10 (MS), or 10-12 (BS) years of experience in pharmaceutical or relate

  • Hands-on project experience in PBPK modeling and simulation through internship, industry research collaboration, or direct industry experience strongly preferred

  • Successful track record of applying PBPK into projects

  • Strong understanding of ADME, PK and DDI concepts as well as significant theoretical and practical understanding of own scientific discipline

  • Focus on and passion for data analysis, solving technical problems and applying new technologies to further scientific goals.

  • Hands-on experience in the use of commercial PBPK modeling software (SimCyp or GastroPlus is preferred)

Loxo Oncology, Inc. (Loxo) currently anticipates that the base salary for the Senior Scientist position level could range from between $89,750 to $131,672 and that the base salary for the Principal Scientist position level could range from between $103,200 to $151,423 and will depend, in part, on the successful candidate’s qualifications for the role, including education and experience. This position also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Loxo provides a comprehensive benefit program to eligible employees, including vacation, medical, dental and vision benefits; participation in a 401(k) plan; life and accidental death and disability coverage; parental leave benefits and employee discounts for certain items. The compensation described above is subject to change and could be higher or lower than the range described above. Further, Loxo reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion.

Available Locations for this Role:

  • US Based-Remote

  • Louisville, Colorado

  • San Diego, CA

Physical Demands/Travel:

The physical demands of this job are consistent with light office duties.

The physical demands here are representative of those that must be met by an employee to successfully perform the essential functions of this job.

Work Environment:

The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job.

*To perform this job successfully, an individual must be able to perform the role and responsibilities satisfactorily. The requirements listed above are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

Loxo Oncology, Inc. is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law).

Loxo Oncology, Inc. (“Loxo”) is committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Loxo, please email for further assistance. Please note, this email address is intended for use to request an accommodation as a part of the application process. Any other correspondence will not receive a response.